爱德华·艾尔利克和他弟弟阿尔冯斯·艾尔利克十分思念在他们还小的时候亡故的母亲，为了再次见到母亲，进行了炼金术中最大的禁忌——人体炼成。可是因为炼成时的反噬，阿尔则失去了全身，爱德失去了左脚，为了换回弟弟，爱德华牺牲自己的右手作为代价将弟弟的灵魂炼成，并将弟弟阿尔冯斯的灵魂固定在一副铠甲上。从此爱德华和阿尔冯斯为了取回他们所失去的一切，开始踏上了找回自己身体的旅程。

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